At the US Gene therapy Academic society 4th annual meeting, the American GenStar Therapeutics Company announced its development to the medium take Maximum adenovirus (MAX-AD) as carrier hemophilia A gene therapy medicine MAX-AD?Factor and CD4 immune body union therapy clinical earlier period test result. GenStar Corporation’s MAX-AD carrier has removed the nearly all adenovirus gene, may insert the goal gene length is early gene treatment carrier 10 times.
It is reported that this experiment’s goal is to examine in the hemophilia A mouse medication postosome the hemoglutination?Factor content and to this therapy immune response.
Finally, gives Shan Huoshuang in the first week dosage MAX-AD?The factor and Shan Huoshuang in the dosage CD4 immune body treatment’s foundation, gives the same dosage once more in the 17th week with the treatment which blends, then can cause to accept two times gives the medicine the mouse in vivo hemoglutination?The factor horizontal straight line rise accepts gives the medicine for the first time two times after it; If can give double dosage MAX-AD promptly in the 57th week?The factor unites Shan Huoshuang the dosage CD4 immune body consolidated treatment the words, this high level hemoglutination?The factor blood density will obtain further maintains.
In addition, the scientist also discovered that with uses MAX-AD only?The factor treatment’s mouse compares, accepts MAX-AD?The factor unites the CD4 immune body treatment the mouse has the immunity side reaction probability to reduce 100 times.
The GenStar Corporation’s scientific researchers this time also carried on to MAX-AD and this company first generation of transgene virus carrier quite have studied, finally indicated that take first generation of viral carrier as medium?The factor medicine initiation mouse immunity side reaction’s probability compares MAX-AD?Factor high 40 times.
In brief, MAX-AD can apply repeatedly does not cause the obvious organism immune response. The researchers thought that this is a gene therapy tremendous progress, because this has brought the hope for the treatment old disease.