Reports and so on South Korean Ko, the application Alpha interferon (IFN-?) treats the hemophilia baby’s chronic hepatitis C is safe effective, has the possibility to obtain the lasting curative effect. Ko et al. take 17 example infection hepatitis C’s hemophilia baby as the objects of study, hemophilia A 15 examples, hemophilia B 2 examples. Conforms to the following standard: Before the treatment, the anti-hepatitis C virus (HCV) immune body masculine gender, in the blood serum has HCV the RNA, ALT level to be bigger than the normal upper limit 1.5 times and continues above 6 months, blood serum hepatitis B virus, human immunodeficiency virus, anti-nuclear immune body and anti-liver - kidney microsome immune body even negative, liver biopsy for chronic hepatitis performance. Gives the following treatment: Hypodermic injection reorganization IFN-? 2a, the dosage is (3.7±0.8) MU/m2/time, 3/weeks, continue for 6 months. Determination blood serum ALT and HCV RNA level. After the treatment had ended, monitors blood serum HCV RNA level 1/in February, continues for 18 months, afterward 1/year. The average revisit time is (3.6±0.6) year. Divides into 3 kinds according to the baby to the IFN response: After continuing the effectiveness (treatment to finish, after 3 year blood serum HCV RNA continued negative), invalid (treatment neutral treatment, after blood serum HCV the RNA even masculine gender) and the recrudescence (treatment had ended, blood serum HCV RNA was negative but in hereafter 3 year internal circulation for masculine gender). (J Pediatr Gastroenterol Nutr 2001,32 ?41) The result showed that in 17 example babies hepatitis C virus genotype 1a 3 examples, 1b 5 examples, 2a 6 examples, 3a 1 example, and some 2 examples for mixed infection (1a +2a). When treatment conclusion in 17 example babies 11 example (65%) ALT level restores normally, simultaneously 9 example (53%) blood serum HCV RNA transfers the negative and the treatment finished 6 months later maintained the negative. In 3 year revisit, 2 example recrudescences, 7 examples (41%) continues effectively, this 7 example baby’s blood serum ALT water average in the treatment starts in the latter 8 weeks to restore normally. To the curative effect different 3 kind of baby’s clinical characteristic, the biochemistry characteristic, the histology characteristic and the virology characteristic perform quite to discover that before continuing the effective group babies to treat, blood serum HCV the RNA level to be lower than the invalid group and the recrudescence group, other aspect not remarkable difference. in 8 example virus gene 1 baby 1 example (13%) to continue effectively, in 6 example virus gene 2 babies 5 examples (83%) to continue effectively.